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In addition, regardless of genotype, it was shown that patients exposed to higher doses of antipsychotics during the 3-year follow-up period also had a greater reduction in GM, and although this could be explained by the fact that in patients with more severe disease symptoms, expecting greater reductions in brain volume required higher doses of medication, studies in monkeys also show that exposure to antipsychotics reduces fresh brain weight and volume by ~10%, independent of treatment with haloperidol or olanzapine [42]
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