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Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

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Once here, ATP7B links the copper to an organelle system known as the trans-Golgi network (TGN) [25,26,27,28,29,30], where both ATPases, ATP7A and ATP7B, normally reside, but with increasing intracellular copper levels, they move to cytoplasmic vesicles nearby the cell periphery, where their primary role is in the excretion of the excess copper from the epithelial cells of the gastrointestinal tract [31]