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Less estrogen can weaken the muscles there, making you need to pee more frequently (and more urgently)
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This might be seen as a network of evidence for the physiologic significance of the revealed BPC 157/NO-system interplay (i.e., BPC 157 was found in in situ hybridization and immunostaining studies in humans to be largely distributed in tissues [20] and may have additional physiologic regulatory roles [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40])