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Glutathione has also emerged a key modulator of xenobiotic toxicity, most notably the persistent organic pollutants which are associated with many diseases of impaired metabolic activity, including diabetes, obesity, and cardiovascular disease

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In order to study the subcellular localization of the 5′-elongated TrxR in vivo , a construct of the full length TrxR fused to the GFP gene (TrxR-GFP) was generated

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