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The intestinal GSH levels are decreased by the FRD, which would explain the increment in the superoxide anion and in the protein carbonyl content
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Subsequent investigations in RGS7 −/− mice reveal that the absence of RGS7 leads to a deceleration in the deactivation kinetics of GABA-activated GIRK channels in hippocampal neurons (Ostrovskaya et al., 2014)
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