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Crosstalk between excitotoxicity and ferroptosis Excitotoxicity is mainly due to excessive glutamate release during ischemia leading to excessive activation of NMDAR, which leads to intracellular calcium overload, ROS-induced oxidative stress, mitochondrial dysfunction, and impaired membrane permeability (Yoo et al., 2017), Ca 2+ overload via glutamate receptor-induced cPLA2 activation produces neurotoxic metabolites such as prostaglandins, leukotrienes, ROS, and platelet-activating factor via AA and lysophospholipid metabolism