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2 Gut microbiota dysbiosis and associated disease Gut dysbiosis has been linked to numerous diseases, including autoimmune disorders, neurodegenerative diseases, metabolic conditions, and inflammatory diseases
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13 An increasing number of studies have shown that SUMOylation is involved in the pathogenesis of osteoporosis, 14 rheumatoid arthritis, 15 and primary and metastatic bone tumours
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