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Because methylcobalamin is classed as a nutritional supplement and is not a licensed prescription only medicine in the UK, it is not available via the NHS and is being offered more and more by non-healthcare and non-prescribing practitioners as a treatment for wellness, fatigue, and to boost energy, without making any medical claims around deficiency, and is rarely combined with a supplement of adenosylcobalamin
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An independent approach, unrelated to gene mutations, involves cell-based therapy, where stem cells hold the potential to restore dysfunctional cells or release tropic factors, facilitating restoration [348]