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[DOI] [PubMed] [Google Scholar] 11.Doessing S., Heinemeier K.M., Holm L., Mackey A.L., Schjerling P., Rennie M., Smith K., Reitelseder S., Kappelgaard A.M., Rasmussen M.H., et al

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That may be a rational design for local GI exposure , where systemic bioavailability may not even be the primary objective