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The ACR guidelines are recommendations, so it’s important that you and your doctor work together to decide on a treatment plan
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The 12mg arm (which produced the 24.2% weight reduction at 48 weeks) followed this retatrutide dosing schedule: Week 1-4: 2mg weekly → Week 5-8: 4mg weekly → Week 9-12: 8mg weekly → Week 13+: 12mg weekly
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