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Variants like C677T and A1298C can reduce enzyme efficiency, potentially leading to higher homocysteine levels and impacting processes like detoxification, neurotransmitter production, and cardiovascular health

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Consideration of variability of these data allows for extrapolation of a range of in vivo equivalent doses across individuals rather than a single value, which more accurately reflects the distribution of population responses that occur from exposure to a chemical (Wetmore et al