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It blocks Ang II AT1 receptors and is a partial agonist of peroxisome proliferator-activated receptor-gamma (PPAR-γ), a nuclear transcription factor that plays a role in the regulation of carbohydrate and lipid metabolism, and suppresses inflammatory gene expression, with this effect being independent of the blood pressure-lowering effects induced by AT1 receptor antagonism, thus showing a marked protective effect on colitis [99]
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