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CRISPR/Cas9 [clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 9] gene editing to disrupt the SlGGP1 uORF produced tomato fruit with greatly increased ascorbate by up to 5-fold (Deslous et al

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The uncontrolled inflammatory mediators circulate through the bloodstream and impact the kidneys, resulting in hemodynamic disturbances within the renal region, endothelial dysfunction in renal vasculature, and mitochondrial dysfunction, culminating in renal impairment as evidenced by elevated creatinine and urea levels (12)