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HO-1 induced by heme pretreatment, provided protection against renal IRI by inhibiting pro-inflammatory cytokine responses

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For example genistein-treated E6 and five human bladder cancer cell lines have exhibited anti-angiogenic effect via downregulating vascular endothelial growth factor (VEGF), platelet-derived growth factor, urokinase plasminogen activator, matrix metalloprotease-2 (MMP-2) and MMP-9 expression