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Higher doses (4.0 to 16.0 ppm) to day-old chicks for a period of 21 days resulted in oral lesions (lesions on their palates and tongues), high mortality rate (evident on the 7th day of ingestion), necrotic lesions in the gizzard, an increased rate of liver hematomas, higher relative spleen and pancreas weight and reduced weight of the bursa of Fabricius decreased