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At a median follow-up of 40.9 months, acalabrutinib demonstrated non-inferiority to ibrutinib in terms of efficacy and was associated with lower rates of cardiovascular (hypertension and atrial fibrillation) and non-cardiac events (diarrhea, myalgia/arthralgia and bleeding), suggesting that greater BTK selectivity may reduce off-target effects, resulting in an improved clinical safety profile