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10.1007/s00239-008-9097-1 Summary Keywords cross-strand disulfide, forbidden disulfide, redox-active disulfide, exaptation, disulfide evolution, CD4 evolution, AKT evolution, post-translational cysteine modification Citation Mohanasundaram KA, Haworth NL, Grover MP, Crowley TM, Goscinski A and Wouters MA (2015) Potential role of glutathione in evolution of thiol-based redox signaling sites in proteins