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NNMT (Nicotinamide N-Methyltransferase) is a cytosolic enzyme that catalyses the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide — producing 1-methylnicotinamide (1-MNA) and S-adenosyl-homocysteine (SAH) as reaction products

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Using Medicare’s RT/LT two-line format for a commercial payer that accepts modifier 50 doesn’t cause a denial, but using the modifier 50 single-line format for a Medicare contractor that expects RT/LT lines can trigger a bilateral edit that delays payment