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Despite decades of controversy following the Women's Health Initiative, contemporary guidance emphasizes that MHT remains the gold standard for treating moderate-to-severe VMS in appropriately selected patients.² Current recommendations support initiating therapy in women younger than 60 years or within 10 years of menopause onset, when the overall benefit-risk profile is most favorable.² Clinical practice has also evolved toward lower effective estrogen doses and greater use of transdermal estradiol, particularly in women with cardiovascular risk factors or concerns regarding venous thromboembolism

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Li S, Wang M, Wang Y, Guo Y, Tao X, Wang X, et al