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A 12-week randomized, double-blind, placebo-controlled study found that a combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 effectively reduced inflammation and alleviated psychiatric symptoms in patients with Major Depressive Disorder (MDD) who were on a gluten-free diet [89]

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Furthermore, mitochondrial NADPH production is dependent on at least 5 mitochondrial enzymes including nicotinamide nucleotide transhydrogenase (NNT), isocitrate dehydrogenase 2 (IDH2), malic enzyme 3 (ME3), mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) and methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L) (4)

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