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maintenance dose once every 2 months or 300 g once a month, but In cases of evident neurological disorders: 1 mg once or twice a week for 2 years) ( In France, the Strasbourg-based CARE B12 research group recommends differing treatment regimens for pernicious anaemia and other causes of B12 deficiency ( In Australia, the Immigrant Health Service of the Royal Children’s Hospital of Melbourne recommends varying treatment regimens based on age of the patient ( g-1mg IM OH-Cbl (preferred) or CN-Cbl daily is recommended on alternate days for 1–2 weeks then 250 g weekly injections until clinically improved, before switching to oral replacement treatment
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Detoxification of Patulin Patulin (PAT, 65 ), a polyketide lactone, exhibits genotoxic, mutagenic, carcinogenic, teratogenic and cytotoxic properties for humans and animals as well as plants [148,149]
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