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In our study, the AEDG peptide was most likely to interact with the linker histones H1/6, as requiring the lowest binding energy (sequence Tyr-Arg-Lys-Thr-Gln, binding energy −64.51 kcal/mol) and H1/3 (sequence His-Pro-Ser-Tyr-Met-Ala-His-Pro-Ala-Arg-Lys, binding energy −56.49 kcal/mol)
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