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Neuronal activity is functionally linked to the local circulation, and an increase in neuronal firing initiates focal vasodilatation of arterioles and capillaries, a phenomenon known as functional hyperemia (Mosso 1880
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Grey matter demyelination also presents in MS – cortical, and hippocampal atrophy is most severe in the progressive stages of MS and is a prominent source of permanent disability [77, 78]
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