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NNMT participates in several differentiation processes including naive-to-primed human embryonic stem cell transition, myogenesis, and both epithelial- and neural-mesenchymal transition in several cancers

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Although FOXO4’s specific effects on mitochondria are not as direct as the other peptides above, it is known to regulate the expression of genes involved in oxidative stress response and energy metabolism which can impact mitochondrial function indirectly (Liu, 2019)