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Moreover, the “negative” effects of RAGE activation cannot always be attributed solely to AGEs

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Subsequent studies have consistently supported the finding of widespread RCD, activated via the intrinsic apoptotic pathway, which includes concurrent elevation of capsase-9, cytochrome C, BAX, and a decrease in anti-apoptotic BCL2, in rat (8, 12, 63, 85, 89, 114, 116, 125, 134, 138–142), mouse (62, 113, 117, 143) and NHP (137, 144–147) models, with both in vitro (62, 85, 113, 114, 116, 139, 140) and in vivo (8, 12, 62, 63, 116, 117, 125, 134, 138, 141–143) experimental protocols