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Furthermore, supplementation with L-GSH in T2DM subjects, resulted in maintained levels of reduced GSH ( Figures 4F–H ), while the group that received placebo had decreased levels of reduced GSH after 3 months ( Figures 4F–H )

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Otherwise, α-tocopherol, a powerful antioxidant, becomes pro-oxidant at high concentrations (Lü et al., 2010)