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The first clinical investigation reporting the results of an intradiscal injection of autologous BM-MSCs was performed by Orozco and colleagues

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in the steady state, the transepithelial passage of small amounts of food-derived antigens and microorganisms participates in the induction of a homeostatic immune response dominated by immune tolerance to dietary antigens 1, 2 and the local production of secretory immunoglobulin A (SIgA), 3 preventing pathogenic and commensal microbes from entering internal compartments