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These cells exhibit smaller mitochondria, denser mitochondrial membranes, reduced or absent cristae, and ruptured outer mitochondrial membranes

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In the phase 1/2 trial, alpelisib (a PI3K inhibitor) plus nab-paclitaxel was well tolerated and showed encouraging efficacy, especially in patients with metastatic PIK3CA -mutated HER2− breast cancer, despite that TNBC has lower efficacy than HR+/HER2− patients