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Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors

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Mason, Selye acknowledged a major weak point in his stress theory, the failure to identify experimentally such a first mediator [293,294]