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Succinate is a product of myeloid and lymphoid cells, but the succinate receptor GPR91 is selectively expressed on monocytes/macrophages, granulocytes, and dendritic cells ( GPR91-/- mice show reduced articular hyperalgesia, neutrophil infiltration and inflammatory cytokines in the joint, and reduced frequency of Th17 cells in the draining lymph nodes ( Evidence has been provided describing succinate as a signaling molecule in the arthritic joint, with macrophages as the recipients of the stimulatory signals ( Figure 2 )
Omeprazole 40 mg
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