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Differences between Tolerance and Tachyphylaxis (Desensitization) in Pharmacology

Both groups subsequently withdrew their nominations, but the FDA elected to evaluate the substances anyway

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Mass balance In the absence of receptor depletion, more precisely in the limit of time scale separation between the receptor depletion and the dynamics of ligand-induced G protein signaling, the total concentration (number) of receptors on the plasma membrane should satisfy the mass balance: Thus, it follows from the mass balance that [ R ] ss can formally be expressed in terms of R o The expressions of the other receptor states are also obtained by employing Eqs