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In addition, gut-derived inflammatory signals-such as lipopolysaccharide (LPS) and pro-inflammatory cytokines including interleukin-6 (IL-6), tumor necrosis factor- α (TNF-α), and interleukin-1β (IL-1β) can disrupt blood–brain barrier (BBB) integrity, activate microglia, and provoke neuroinflammation, contributing to sleep disturbances (15)

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This process gradually reduces pigmentation and encourages a clearer complexion