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EDN, as its name implies, was discovered as the neurotoxin that accounted for the Gordon phenomenon, described in 1933, in which splenic extracts from patients with the Hodgkin’s disease caused severe damage to myelinated neurons in experimental animals.87 Distinctive hexagonal, bipyramidal crystals were initially described in 1853 in a patient with leukemia and later, in 1872, in the sputa of asthmatic patients

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When the solution pH drops below 4.5, the imidazole ring of the histidine residue becomes fully protonated