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Interestingly, this decline in NAD+ and increase in CD38 with age can potentially be attributed to another age-related phenomenon: the accumulation of senescent cells, cells that exhibit permanent growth arrest

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10.1523/jneurosci.20-01-00326.2000 [DOI] [PMC free article] [PubMed] [Google Scholar] Ohnishi H., Mizuno S., Nakamura T