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This unfortunately adds ticagrelor to a growing list of unsuccessful medications for SCD, which includes senicapoc, prasugrel, regadenoson, sevuparin, poloxamer 188, olinciguat, and rivipansel [35]
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Moreover, considering the seno-antigens typically have important roles in intracellular signaling and regulation of immune responses, it remains to be investigated whether the inhibition of uPAR expressing cells could result in side effects such as impaired immune response, and their long-term effect on health status and lifespan remains poorly understood