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Only GlyNAC supplementation in OA resulted in significantly improved (a) GSH concentrations by 121% after 2-weeks, and by 164% after 16-weeks to levels not different from YA-0w (Supplementary Figure S1), and (b) muscle GCLC and GSS expression (with a trend toward improvement for GCLM

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Although multiple therapeutic strategies targeting different pathological processes of MASH, including lipid accumulation, inflammation, and fibrosis, are under clinical trials, only two pharmacologic treatment, Resmetirom, a thyroid hormone receptor-β agonist, and Semaglutide, a GLP-1 receptor agonist, have been approved by the FDA for clinical use 4,5,6