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Notably, protocatechuic aldehyde blocks cisplatin-induced AKI by suppressing Nox-mediated oxidative stress and inflammation without affecting the antitumor activity of cisplatin [127]
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Nevertheless, changes in the endothelial compartment caused by Tbx1 mutation could affect brain metabolism by altering signals or metabolite exchange across cell membranes, which could in turn cause or contribute to the diffuse brain phenotypes observed in Tbx1 +/− mice
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