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Interesting findings were detected when evaluating the effects of a combination of pesticides: maneb, a dithiocarbamate fungicide, has low toxicity on its own [83], but it was found to change the toxicokinetics of paraquat through inhibition of the mitochondrial complex III function in rat brain and mitochondrial dysfunction in primary mesencephalic neuron culture [84, 85]

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but it is especially abundant in the liver