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Nonrecycling (Lysosomal Pathway) Leading to Long-Term Desensitization of β 2 Adrenoceptors For most GPCRs, once endocytosed, the inactive receptor, now present in an endosome, is sorted to one of two finite destinations: 1) the degradative pathway by lysosomes or proteasomes or 2) renewal (“recycling”) pathways either via the trans-Golgi network or directly to the plasma membrane (Bao et al., 2020

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