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Signature scores from a curated list of genes categorized as HIF-1α targets, or associated to oxidative phosphorylation and glycolysis pathways were then specifically assessed (table S2) on the monocyte/cDC macrocluster
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Nitrite bioactivation Inorganic nitrite is the conjugate base of nitrous acid, which has a much higher p K a [3.11 at 37°C (da Silva et al ., 2006)] than nitric acid (conjugate acid of nitrate, p K a = −1.3), consistent with nitrite protonation under certain physiological circumstances such as in the low pH of the stomach and, thus, increased lipid solubility
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