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[149] demonstrated that hydrogen peroxide-mediated barrier defects are blocked by a TGF-α antibody in intestinal Caco-2 cells, indicating that the oxidative stress induces cleavage and release of endogenous TGF-α and that the released TGF-α contributes to barrier impairment
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Pathogens, xenobiotics and food can disrupt the intestinal barrier, promoting systemic inflammation and tissue damage
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