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Integration of these behavioral and neuromodulatory strategies with pharmacologic interventions allows a multidimensional, personalized approach, where treatment is matched to both phenotypic and mechanistic characteristics, ultimately improving functional outcomes [166]

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Following granule exocytosis, perforin facilitates the delivery of granzymes into the cytosol of the target cell where they cleave numerous substrates, including caspases, resulting in the rapid induction of apoptosis 7,8