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The process of matrix metalloproteinase (MMP)-mediated shearing of the CD44 extracellular structural domain to cleavage of the intracellular structural domain to the final release of intracellular structural domain fragments (ICDs) to act as signaling transcription molecules is strictly sequential (45)

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A new Ehlers–Danlos syndrome with craniofacial characteristics, multiple congenital contractures, progressive joint and skin laxity, and multisystem fragility-related manifestations