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A widely cited study by Kraus and colleagues used genetic knockdown in mice

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beyond reason There are data to support that NAC may increase intraplatelet levels of glutathione and decrease ROS .7 Glutathione itself has poor absorption and does not seem to improve markers of oxidative stress or even change the measured levels of endogenous glutathione, and there is insufficient data on other modes of administration .8–10 However, magnetic resonance spectroscopy (MRS) has shown increased blood and brain glutathione11 as a result of NAC infusions