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The methylation cycle, as pictured above, is the biochemical process that allows the body to move a methyl group that can go on to attach to various molecules to activate DNA, detoxify estrogen and perform other important cellular functions
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This could contribute to the etiology of autoimmunity by supplying survival signals to B cells that have accidentally developed auto-reactivity against nuclear and apoptosis-related autoantigens during somatic diversification, a process that randomly inserts mutations into the variable region of IgG
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