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Despite preclinical experiments showing that stimulating the nuclear receptor peroxisome proliferator–activated receptor-gamma (PPARγ) reduced skin fibrosis in scleroderma, no such change was observed in a phase 2 trial testing the efficacy of lanifibranor, a small-molecule PPARγ agonist (NCT02503644)
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At 15 min, 24 h and 48 h post-ligation, we assessed hemorrhagic congestive areas in the stomach, duodenum, jejunum, cecum and ascending colon
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