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in a prospective randomized trial including 38 patients (7 with pernicious anemia [18,4%]), have reported improvement of hematological parameters and vitamin B12 levels (mean value: 907 pg/mL), after 4 months of oral cyanocobalamin replacement using a much higher dose (i.e

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We further identified DT-109 as a glycine-based treatment for atherosclerosis, independent of its lipid/glucose-lowering effects, and uncovered induction of de novo GSH synthesis and antioxidant defense as a central mechanism of action (Fig