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We should also mention the markers of ROS generation, for example XO, which causes the conversion of xanthine to UA, which is not only an antioxidant but also a proinflammatory factor by influencing the NALP3 inflammasome

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This preclinical data demonstrates the efficacy of b-AP15 in MM disease models and validates DUBs as potential therapeutic targets, providing a basis for future clinical studies on USP14/UCHL5 inhibitors in patients resistant to PIs [48]