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These changes contribute to the alleviation of intestinal inflammation and restoration of intestinal barrier integrity, thereby mitigating liver inflammation and injury via the gut-liver axis ( 4.4.4 Da-Huang-Xiao-Shi decoction In the α-naphthylisothiocyanate (ANIT)-induced cholestasis model of Sprague-Dawley rats, the experimentally effective dose of DHXSD (4.72 g/kg via intragastric administration for 7 consecutive days) (Wang et al., 2022b) upregulates the abundance of beneficial bacteria such as Lactobacillus , thereby promoting the production of SCFAs