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In parallel, curcumin demonstrably modulates intestinal transport and metabolism: contemporary mechanistic studies show P-glycoprotein inhibition and interaction with CYP3A4, while a human PK trial found oral curcumin reduced bioavailability of a P-gp/CYP3A4 probe substrate via apparent CYP3A4 activation, highlighting formulation- and context-dependent effects [173,204]
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